USA Best Regional Burger Serving Chains.

Milo's Hamburgers, a small-scale Alabama burger franchise (with just 20 locations currently), was started in 1946 in Birmingham by Milo Carlton, a former U.S. Army mess cook.

Milo's Hamburgers

Cook Out first opened its doors in 1989 and now has 313 locations across ten states. The burger and BBQ chain was founded in North Carolina and is largely focused in the Southeast.

Cook Out

The Texas company, founded in 1950, is famous for its trademark item—a burger "so enormous that it [needs] two hands to handle." Whataburger, like Culver's, punches above its weight in terms of sales: the brand earned more than $2.7 billion in 2020 while having just 844 outlets.

Whataburger

The Wisconsin-based brand has been in the better burger business for over 40 years, having initially opened its doors in 1984. It is famous for its iconic ButterBurger, which is produced with fresh-never-frozen beef.

Culver's

IN-N-OUT BURGER has long been a cult favorite fast food staple for West Coast locals who visit for Double-Double cheeseburgers, maybe ordered "Animal Style" from the Not-So-Secret Menu.

IN-N-OUT BURGER

Hattie B's has a devoted fan base of hot chicken fans who come for the sandwiches and platters. The heat settings range from no-heat Southern to Shut the Cluck Up!!! with a significant burn factor.

HATTIE B'S HOT CHICKEN

Biscuitville is a family-owned chain of restaurants specialized on Southern cuisine, with 55 sites in North Carolina and Virginia. Every 15 minutes, new biscuits are cooked for the morning sandwich menu.

BISCUITVILLE

Schoop's Hamburgers has been enjoyed by residents of Indiana's Calumet Region southeast of Chicago since 1948.

SCHOOP'S HAMBURGERS

What began in Lincoln, Nebraska in 1949 has only grown to three other states: Iowa, Colorado, and Kansas, where the distinctive Runza sandwich is loaded with ground beef, onions, spices, and cabbage. In addition to these Runzas, customers can choose burgers, sandwiches, and traditional sides.

RUNZA

PDQ is an abbreviation for "People Dedicated to Quality," which defines founders Bob and Nick, who set out to build a new type of fast food restaurant with a focus on fresh, quick, and economical meals.

PDQ